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PDE7A

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(Redirected from PDE7A (gene))
PDE7A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDE7A, HCP1, PDE7, phosphodiesterase 7A
External IDsOMIM: 171885; MGI: 1202402; HomoloGene: 1956; GeneCards: PDE7A; OMA:PDE7A - orthologs
EC number3.1.4.53
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242318
NM_002603
NM_002604

NM_001122759
NM_008802

RefSeq (protein)

NP_001229247
NP_002594

NP_001116231
NP_032828

Location (UCSC)Chr 8: 65.71 – 65.84 MbChr 3: 19.28 – 19.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.[5][6][7] Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205268Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069094Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. doi:10.1016/S0021-9258(18)31474-1. PMID 8389765.
  6. ^ Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
  7. ^ "Entrez Gene: PDE7A phosphodiesterase 7A".

Further reading

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