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PDE11A

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PDE11A
Identifiers
AliasesPDE11A, PPNAD2, phosphodiesterase 11A
External IDsOMIM: 604961; MGI: 3036251; HomoloGene: 56763; GeneCards: PDE11A; OMA:PDE11A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016953
NM_001077196
NM_001077197
NM_001077358

NM_001081033

RefSeq (protein)

NP_001070664
NP_001070665
NP_001070826
NP_058649

NP_001074502

Location (UCSC)n/aChr 2: 75.82 – 76.17 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.[4][5]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing's disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Inhibitors

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References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075270Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.
  5. ^ a b "Entrez Gene: PDE11A phosphodiesterase 11A".
  6. ^ Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. hdl:2345/2934. PMID 22284362.

Further reading

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