Olfactomedin 1

OLFM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XAT
Identifiers
Aliases	OLFM1, AMY, NOE1, NOELIN1, OlfA, olfactomedin 1
External IDs	OMIM: 605366; MGI: 1860437; HomoloGene: 8612; GeneCards: OLFM1; OMA:OLFM1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 135,075,422 bp End 135,121,180 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 28,083,004 bp End 28,120,748 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 10 frontal pole primary visual cortex superior frontal gyrus right frontal lobe dorsolateral prefrontal cortex orbitofrontal cortex Brodmann area 46 Brodmann area 23 Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex hippocampus proper primary motor cortex prefrontal cortex piriform cortex anterior amygdaloid area subiculum cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular region cell junction axon soma perikaryon axonal growth cone synapse cell projection endoplasmic reticulum extracellular space Biological process multicellular organism development atrioventricular valve formation neuronal signal transduction positive regulation of gene expression regulation of axon extension positive regulation of epithelial to mesenchymal transition negative regulation of gene expression nervous system development cardiac epithelial to mesenchymal transition positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10439 56177 Ensembl ENSG00000130558 ENSMUSG00000026833 UniProt Q99784 O88998 RefSeq (mRNA) NM_058199 NM_001282611 NM_001282612 NM_006334 NM_014279 NM_001038612 NM_001038613 NM_001038614 NM_019498 RefSeq (protein) NP_001269540 NP_001269541 NP_006325 NP_055094 NP_001033701 NP_001033702 NP_001033703 NP_062371 Location (UCSC) Chr 9: 135.08 – 135.12 Mb Chr 2: 28.08 – 28.12 Mb PubMed search
Wikidata
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Olfactomedin 1, also known as noelin 1 or pancortin, is a protein that in humans is encoded by the OLFM1 gene. The name noelin stands for "neuronal olfactomedin-related endoplasmic reticulum-localized 1".

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.

Cancer

OLFM1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ, Brandon NJ (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677. S2CID 25119660.