MYT1L

MYT1L
Identifiers
Aliases	MYT1L, NZF1, ZC2HC4B, MRD39, ZC2H2C2, myelin transcription factor 1 like, myT1-L
External IDs	OMIM: 613084; MGI: 1100511; HomoloGene: 7435; GeneCards: MYT1L; OMA:MYT1L - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	2,331,664 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	29,923,213 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; Region I of hippocampus proper; ; Brodmann area 46; ; primary visual cortex; ; orbitofrontal cortex; ; postcentral gyrus; ; middle temporal gyrus; ; superior frontal gyrus; ; entorhinal cortex;
	Top expressed in
	olfactory tubercle; ; cingulate gyrus; ; anterior amygdaloid area; ; lateral septal nucleus; ; nucleus accumbens; ; Region I of hippocampus proper; ; subiculum; ; ventromedial nucleus; ; substantia nigra; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; zinc ion binding; metal ion binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus; chromosome;
Biological process	multicellular organism development; cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; nervous system development; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; neuron differentiation; neuron fate commitment; neuron fate specification; neuron development; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	23040
	17933
	ENSG00000186487
	ENSMUSG00000061911
	Q9UL68
	P97500
NM_001303052; NM_015025; NM_001329844; NM_001329845; NM_001329846;
	NM_001329847; NM_001329848; NM_001329849; NM_001329851; NM_001329852
NM_001093775; NM_001093776; NM_001093778; NM_008666; NM_001361655;
	NM_001361656; NM_001361657; NM_001361658; NM_001361659; NM_001361660
NP_001289981; NP_001316773; NP_001316774; NP_001316775; NP_001316776;
	NP_001316777; NP_001316778; NP_001316780; NP_001316781; NP_055840
NP_001087244; NP_001087245; NP_001087247; NP_032692; NP_001348584;
	NP_001348585; NP_001348586; NP_001348587; NP_001348588; NP_001348589
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin transcription factor 1 like is a protein that in humans is encoded by the MYT1L gene. ^[5]

Function

This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186487 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Myelin transcription factor 1 like". Retrieved 2018-02-05.

Vrijenhoek T, Buizer-Voskamp JE, van der Stelt I, Strengman E, Sabatti C, Geurts van Kessel A, Brunner HG, Ophoff RA, Veltman JA (2008). "Recurrent CNVs disrupt three candidate genes in schizophrenia patients". Am. J. Hum. Genet. 83 (4): 504–10. doi:10.1016/j.ajhg.2008.09.011. PMC 2561936. PMID 18940311.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Wang T, Zeng Z, Li T, Liu J, Li J, Li Y, Zhao Q, Wei Z, Wang Y, Li B, Feng G, He L, Shi Y (2010). "Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population". PLOS ONE. 5 (10): e13662. Bibcode:2010PLoSO...513662W. doi:10.1371/journal.pone.0013662. PMC 2965102. PMID 21048971.
Wang T, Zeng Z, Li T, Liu J, Li J, Li Y, Zhao Q, Wei Z, Wang Y, Li B, Feng G, He L, Shi Y (2010). "Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population". PLOS ONE. 5 (10): e13662. Bibcode:2010PLoSO...513662W. doi:10.1371/journal.pone.0013662. PMC 2965102. PMID 21048971.
Li W, Wang X, Zhao J, Lin J, Song XQ, Yang Y, Jiang C, Xiao B, Yang G, Zhang HX, Lv LX (2012). "Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population". Genes Brain Behav. 11 (1): 87–93. doi:10.1111/j.1601-183X.2011.00734.x. PMID 21923761. S2CID 2280688.
Stevens SJ, van Ravenswaaij-Arts CM, Janssen JW, Klein Wassink-Ruiter JS, van Essen AJ, Dijkhuizen T, van Rheenen J, Heuts-Vijgen R, Stegmann AP, Smeets EE, Engelen JJ (2011). "MYT1L is a candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions". Am. J. Med. Genet. A. 155A (11): 2739–45. doi:10.1002/ajmg.a.34274. PMID 21990140. S2CID 19484566.
Meyer KJ, Axelsen MS, Sheffield VC, Patil SR, Wassink TH (2012). "Germline mosaic transmission of a novel duplication of PXDN and MYT1L to two male half-siblings with autism". Psychiatr. Genet. 22 (3): 137–40. doi:10.1097/YPG.0b013e32834dc3f5. PMC 3309069. PMID 22157634.
Lee Y, Mattai A, Long R, Rapoport JL, Gogtay N, Addington AM (2012). "Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophrenia". Psychiatr. Genet. 22 (4): 206–9. doi:10.1097/YPG.0b013e328353ae3d. PMC 3384746. PMID 22547139.
Rio M, Royer G, Gobin S, de Blois MC, Ozilou C, Bernheim A, Nizon M, Munnich A, Bonnefont JP, Romana S, Vekemans M, Turleau C, Malan V (2013). "Monozygotic twins discordant for submicroscopic chromosomal anomalies in 2p25.3 region detected by array CGH". Clin. Genet. 84 (1): 31–6. doi:10.1111/cge.12036. PMID 23061379. S2CID 23829301.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186487 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Myelin transcription factor 1 like". Retrieved 2018-02-05.

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Function

References

Further reading