Multiple c2 domains, transmembrane 2

MCTP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EP6
Identifiers
Aliases	MCTP2, multiple C2 and transmembrane domain containing 2
External IDs	OMIM: 616297; MGI: 2685335; HomoloGene: 69254; GeneCards: MCTP2; OMA:MCTP2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	94,483,952 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	71,956,356 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; secondary oocyte; ; buccal mucosa cell; ; blood; ; visceral pleura; ; parietal pleura; ; spleen; ; bone marrow; ; bone marrow cells; ; mucosa of sigmoid colon;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; granulocyte; ; lumbar spinal ganglion; ; lacrimal gland; ; Paneth cell; ; left lobe of liver; ; submandibular gland; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium-dependent phospholipid binding; calcium ion binding;
Cellular component	integral component of membrane; endoplasmic reticulum; membrane; nucleoplasm; cytosol; synaptic vesicle membrane;
Biological process	multicellular organism development; calcium-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	55784
	244049
	ENSG00000140563
	ENSMUSG00000032776
	Q6DN12
	Q5RJH2
	NM_001159643; NM_001159644; NM_018349
	NM_001024703
	NP_001153115; NP_001153116; NP_060819
	NP_001019874
	Wikidata
View/Edit Human	View/Edit Mouse

Multiple C2 domains, transmembrane 2 is a protein that in humans is encoded by the MCTP2 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140563 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032776 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Multiple C2 domains, transmembrane 2". Retrieved 2016-11-17.

Shin OH, Han W, Wang Y, Südhof TC (2005). "Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties". J. Biol. Chem. 280 (2): 1641–51. doi:10.1074/jbc.M407305200. PMID 15528213.
Verma R, Holmans P, Knowles JA, Grover D, Evgrafov OV, Crowe RR, Scheftner WA, Weissman MM, DePaulo JR, Potash JB, Levinson DF (2008). "Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3". Biol. Psychiatry. 63 (12): 1185–9. doi:10.1016/j.biopsych.2008.02.005. PMC 2435230. PMID 18367154.
Djurovic S, Le Hellard S, Kähler AK, Jönsson EG, Agartz I, Steen VM, Hall H, Wang AG, Rasmussen HB, Melle I, Werge T, Andreassen OA (2009). "Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)". Psychiatry Res. 168 (3): 256–8. doi:10.1016/j.psychres.2008.08.007. PMID 19223264. S2CID 31236485.
Djurovic S, Le Hellard S, Kähler AK, Jönsson EG, Agartz I, Steen VM, Hall H, Wang AG, Rasmussen HB, Melle I, Werge T, Andreassen OA (2009). "Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)". Psychiatry Res. 168 (3): 256–8. doi:10.1016/j.psychres.2008.08.007. PMID 19223264. S2CID 31236485.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140563 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032776 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Multiple C2 domains, transmembrane 2". Retrieved 2016-11-17.

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References

Further reading