Anisindione

Anisindione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Oral
ATC code	none;
Identifiers
	IUPAC name 2-(4-methoxyphenyl)indene-1,3-dione;
CAS Number	117-37-3 ;
PubChem CID	2197;
IUPHAR/BPS	6960;
DrugBank	DB01125 ;
ChemSpider	2112 ;
UNII	S747T1ERAJ;
KEGG	D07457 ;
ChEBI	CHEBI:133809 ;
ChEMBL	ChEMBL712 ;
CompTox Dashboard (EPA)	DTXSID3022611 ;
ECHA InfoCard	100.003.806
Chemical and physical data
Formula	C16H12O3
Molar mass	252.269 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2c1ccccc1C(=O)C2c3ccc(OC)cc3;
	InChI InChI=1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3 ; Key:XRCFXMGQEVUZFC-UHFFFAOYSA-N ;
	(verify)

Anisindione (brand name Miradon) is a synthetic anticoagulant and an 1,3-indandione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.^[1]

References

^ Matschinske J, Salgado-Albarrán M, Sadegh S, Bongiovanni D, Baumbach J, Blumenthal DB (November 2020). "Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment Through Hypothesis-Driven Systems Medicine Using CoVex". Assay and Drug Development Technologies. 18 (8): 348–355. doi:10.1089/adt.2020.1010. PMC 7703307. PMID 33164550.

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[1] Matschinske J, Salgado-Albarrán M, Sadegh S, Bongiovanni D, Baumbach J, Blumenthal DB (November 2020). "Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment Through Hypothesis-Driven Systems Medicine Using CoVex". Assay and Drug Development Technologies. 18 (8): 348–355. doi:10.1089/adt.2020.1010. PMC 7703307. PMID 33164550.

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