Methylprednisolone succinate

Methylprednisolone succinate

Clinical data
Trade names	Solu-Medrol, Solu-Medrone, Urbason, others
Other names	Methylprednisolone hemisuccinate; 6α-Methylprednisolone 21-hemisuccinate
AHFS/Drugs.com	Monograph
License data	US DailyMed: Methylprednisolone succinate
Routes of administration	Intravenous injection
Drug class	Corticosteroid; Glucocorticoid
ATC code	D07AA01 (WHO)
Legal status
Legal status	CA: ℞-only US: ℞-only
Identifiers
IUPAC name 4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
CAS Number	2921-57-5
PubChem CID	16923
DrugBank	DB14644
ChemSpider	16034
UNII	5GMR90S4KN
KEGG	D05000
ChEBI	CHEBI:135765
ChEMBL	ChEMBL1201265
CompTox Dashboard (EPA)	DTXSID2023303
ECHA InfoCard	100.017.416
Chemical and physical data
Formula	C26H34O8
Molar mass	474.550 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O
InChI InChI=1S/C26H34O8/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31)/t14-,16-,17-,19-,23+,24-,25-,26-/m0/s1 Key:IMBXEJJVJRTNOW-XYMSELFBSA-N

Methylprednisolone succinate, sold under the brand name Solu-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 succinate ester of methylprednisolone—which is used by intravenous administration. Methylprednisolone succinate is provided as two different salts when used as a pharmaceutical drug: a sodium salt (methylprednisolone sodium succinate; brand name Solu-Medrol, others) and a hydrogen salt (methylprednisolone hemisuccinate or methylprednisolone hydrogen succinate; brand name Urbason).

Methylprednisolone succinate was approved for medical use in the United States in 1959.