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MTCP1

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MTCP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMTCP1, P13p8mature T-cell proliferation 1, mature T cell proliferation 1, TCL1C
External IDsOMIM: 300116; MGI: 102699; HomoloGene: 82921; GeneCards: MTCP1; OMA:MTCP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014221
NM_001018025

NM_001039373

RefSeq (protein)

NP_001018025

NP_001281206
NP_034969
NP_001034462

Location (UCSC)Chr X: 155.06 – 155.15 MbChr X: 74.45 – 74.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein p13 MTCP-1 is a protein that in humans is encoded by the MTCP1 gene.[5][6][7][8]

Function

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This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.[8]

Interactions

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MTCP1 has been shown to interact with AKT1.[9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214827Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031200Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (September 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene. 8 (9): 2475–83. PMID 8361760.
  6. ^ Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH (July 1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood. 87 (5): 1923–7. doi:10.1182/blood.V87.5.1923.1923. PMID 8634440.
  7. ^ Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C (September 1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J Biomol NMR. 11 (3): 337–54. doi:10.1023/A:1008279616063. PMID 9691281. S2CID 22862333.
  8. ^ a b "Entrez Gene: MTCP1 mature T-cell proliferation 1".
  9. ^ Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
  10. ^ Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.

Further reading

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