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MPP6

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(Redirected from MPP6 (gene))
PALS2
Identifiers
AliasesPALS2, VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T
External IDsOMIM: 606959; MGI: 1927340; HomoloGene: 22976; GeneCards: PALS2; OMA:PALS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303037
NM_016447

RefSeq (protein)

NP_001289966
NP_057531

NP_001158205
NP_001158206
NP_064323
NP_001348176
NP_001348177

Location (UCSC)Chr 7: 24.57 – 24.69 MbChr 6: 50.09 – 50.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.[5][6][7]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001).[supplied by OMIM][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105926Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038388Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
  6. ^ Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
  7. ^ a b "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)".

Further reading

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