MHC class I polypeptide–related sequence B

MICB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JE6, 2WY3
Identifiers
Aliases	MICB, PERB11.2, MHC class I polypeptide-related sequence B
External IDs	OMIM: 602436; MGI: 2179989; HomoloGene: 88329; GeneCards: MICB; OMA:MICB - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,494,881 bp End 31,511,124 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 9.35 cM Start 18,573,891 bp End 18,599,327 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood stromal cell of endometrium lymph node bone marrow gonad bone marrow cells spleen appendix Top expressed in urinary bladder uterus lung ovary white adipose tissue adrenal gland zone of skin esophagus muscle tissue skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function natural killer cell lectin-like receptor binding Cellular component integral component of membrane cell surface plasma membrane membrane extracellular space external side of plasma membrane Biological process immune system process gamma-delta T cell activation viral process response to heat cytolysis adaptive immune response response to oxidative stress response to retinoic acid T cell mediated cytotoxicity natural killer cell mediated cytotoxicity regulation of immune response immune response-activating cell surface receptor signaling pathway immune response natural killer cell activation susceptibility to natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4277 243864 Ensembl ENSG00000231179 ENSG00000224378 ENSG00000206449 ENSG00000227772 ENSG00000238289 ENSG00000231372 ENSG00000234218 ENSG00000204516 ENSMUSG00000040987 UniProt Q29980 Q8HWE5 RefSeq (mRNA) NM_001289160 NM_001289161 NM_005931 NM_153760 NM_153761 RefSeq (protein) NP_001276089 NP_001276090 NP_005922 NP_715641 NP_715642 Location (UCSC) Chr 6: 31.49 – 31.51 Mb Chr 7: 18.57 – 18.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.

See also

• MICA

Further reading

• Braud VM, Allan DS, McMichael AJ (Feb 1999). "Functions of nonclassical MHC and non-MHC-encoded class I molecules". Current Opinion in Immunology. 11 (1): 100–8. doi:10.1016/S0952-7915(99)80018-1. PMID 10047540.
• Borrego F, Kabat J, Kim DK, Lieto L, Maasho K, Peña J, Solana R, Coligan JE (Feb 2002). "Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells". Molecular Immunology. 38 (9): 637–60. doi:10.1016/S0161-5890(01)00107-9. PMID 11858820.
• Leelayuwat C, Townend DC, Degli-Esposti MA, Abraham LJ, Dawkins RL (1994). "A new polymorphic and multicopy MHC gene family related to nonmammalian class I". Immunogenetics. 40 (5): 339–51. doi:10.1007/BF01246675. PMID 7927538. S2CID 10504768.
• Bahram S, Spies T (1996). "Nucleotide sequence of a human MHC class I MICB cDNA". Immunogenetics. 43 (4): 230–3. doi:10.1007/BF00587305. PMID 8575823.
• Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Jan 1996). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics. 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. Bibcode:1996PNAS...9312445G. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.
• Bahram S, Shiina T, Oka A, Tamiya G, Inoko H (1997). "Genomic structure of the human MHC class I MICB gene". Immunogenetics. 45 (2): 161–2. doi:10.1007/s002510050184. PMID 8952966. S2CID 26270690.
• Gaudieri S, Leelayuwat C, Townend DC, Mullberg J, Cosman D, Dawkins RL (1997). "Allelic and interlocus comparison of the PERB11 multigene family in the MHC". Immunogenetics. 45 (3): 209–16. doi:10.1007/s002510050191. PMID 8995188. S2CID 6658841.
• Pellet P, Renaud M, Fodil N, Laloux L, Inoko H, Hauptmann G, Debré P, Bahram S, Theodorou I (1997). "Allelic repertoire of the human MICB gene". Immunogenetics. 46 (5): 434–6. doi:10.1007/s002510050299. PMID 9271635. S2CID 7799593.
• Ando H, Mizuki N, Ota M, Yamazaki M, Ohno S, Goto K, Miyata Y, Wakisaka K, Bahram S, Inoko H (1997). "Allelic variants of the human MHC class I chain-related B gene (MICB)". Immunogenetics. 46 (6): 499–508. doi:10.1007/s002510050311. PMID 9321430. S2CID 1912407.
• Groh V, Steinle A, Bauer S, Spies T (Mar 1998). "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells". Science. 279 (5357): 1737–40. doi:10.1126/science.279.5357.1737. PMID 9497295.
• Visser CJ, Tilanus MG, Schaeffer V, Tatari Z, Tamouza R, Janin A, Charron D (Jun 1998). "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles". Tissue Antigens. 51 (6): 649–52. doi:10.1111/j.1399-0039.1998.tb03008.x. PMID 9694358.
• Steinle A, Groh V, Spies T (Oct 1998). "Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules". Proceedings of the National Academy of Sciences of the United States of America. 95 (21): 12510–5. Bibcode:1998PNAS...9512510S. doi:10.1073/pnas.95.21.12510. PMC 22861. PMID 9770516.
• Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T (Jun 1999). "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6879–84. Bibcode:1999PNAS...96.6879G. doi:10.1073/pnas.96.12.6879. PMC 22010. PMID 10359807.
• Tay GK, Hui J, Gaudieri S, Schmitt-Egenolf M, Martinez OP, Leelayuwat C, Williamson JF, Eiermann TH, Dawkins RL (Mar 2000). "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis". Clinical and Experimental Immunology. 119 (3): 553–8. doi:10.1046/j.1365-2249.2000.01140.x. PMC 1905592. PMID 10691930.
• Fischer G, Pérez-Rodríguez M, Argüello JR, Cox ST, McWhinnie A, Travers PJ, Madrigal JA (Feb 2000). "Three novel MICB alleles". Tissue Antigens. 55 (2): 166–70. doi:10.1034/j.1399-0039.2000.550210.x. PMID 10746790.
• Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL (Jun 2000). "Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice". Immunity. 12 (6): 721–7. doi:10.1016/S1074-7613(00)80222-8. PMID 10894171.