Sabarubicin

Sabarubicin
Clinical data
ATC code	none;
Identifiers
CAS Number	211100-13-9 ;
PubChem CID	151897;
ChemSpider	133880;
UNII	XS499WOZ93;
ChEMBL	ChEMBL591251;
CompTox Dashboard (EPA)	DTXSID30870233 ;
Chemical and physical data
Formula	C32H37NO13
Molar mass	643.642 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@@H](O[C@H](C[C@@H]2O)O[C@H]3C[C@@](Cc4c3c(c5c(c4O)C(=O)c6ccccc6C5=O)O)(C(=O)CO)O)C)N)O;
	InChI InChI=InChI=1S/C32H37NO13/c1-12-26(37)17(33)7-21(43-12)46-31-13(2)44-22(8-18(31)35)45-19-10-32(42,20(36)11-34)9-16-23(19)30(41)25-24(29(16)40)27(38)14-5-3-4-6-15(14)28(25)39/h3-6,12-13,17-19,21-22,26,31,34-35,37,40-42H,7-11,33H2,1-2H3/t12-,13-,17-,18-,19-,21-,22-,26+,31-,32-/m0/s1;

Sabarubicin (MEN-10755), a disaccharide analog of doxorubicin, is used for the treatment of small cell lung cancer (SCLC).^[1] It has been seen to show superior antitumour efficacy, which is purported to be linked to the activation of p53-independent apoptosis^[2]

References

^ Committee for Orphan Medicinal Products (6 October 2009). "Public summary of positive opinion for orphan designation of sabarubicin for the treatment of small cell lung cancer" (PDF). European Medicines Agency.
^ Arcamone FM (2008). "Sabarubicin". Topics in Current Chemistry. 283: 171–89. doi:10.1007/128_2007_1. PMID 23605632.

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