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MED7

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MED7
Identifiers
AliasesMED7, ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDsOMIM: 605045; MGI: 1913463; HomoloGene: 3153; GeneCards: MED7; OMA:MED7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004270
NM_001100816

NM_001104530
NM_001104556
NM_001104557
NM_025426

RefSeq (protein)

NP_001094286
NP_004261

NP_001098000
NP_001098026
NP_001098027
NP_079702

Location (UCSC)Chr 5: 157.14 – 157.16 MbChr 11: 46.33 – 46.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.[5][6]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155868Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020397Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl:11858/00-001M-0000-0019-A36A-8. PMID 9989412. S2CID 4405569.
  6. ^ a b "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa".

Further reading

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