Mycobacterium microti
| Mycobacterium microti | |
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| Species: | M. microti
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| Binomial name | |
| Mycobacterium microti Reed 1957, ATCC 19422
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Mycobacterium microti is a member of the Mycobacterium tuberculosis complex (MTBC) known as the 'Vole bacillus', first described as a pathogen of field voles in England.[1]
Description
[edit]Gram-positive, nonmotile, acid-fast rods.
Colony characteristics
- Variable colony morphology, buff in colour, either rough or smooth.
Physiology
- Slow growth on glycerol-free egg media at 37 °C often requiring incubation for 28–60 days. May adapt tolerance to glycerol. May fail to grow in liquid media.
- Usually susceptible to the first line anti tuberculosis antibiotics isoniazid, ethambutol, rifampin, streptomycin and pyrazinamide.
Differential characteristics
Commercially available nucleic acid hybridisation assays are widely used to identify members of the M. tuberculosis complex..
Differentiation between individual members of the M tuberculosis complex is possible using a variety of molecular techniques, and individual strains within a species may be further distinguished using a variety of molecular typing methods.
Pathogenesis
[edit]Cause of naturally acquired generalized tuberculosis in voles and other mammals, including cats and new world camelids such as llamas. Human infections are rare, but do occur in both immunocompromised and apparently immunocompetent patients.[2][3]
Type strain
[edit]Strain ATCC 19422 = CIP 104256 = NCTC 8710.
References
[edit]- ^ Wells, A Q (1937). "Tuberculosis in wild voles". Lancet. 229 (5934): 1221. doi:10.1016/S0140-6736(00)83505-9. S2CID 2364438.
- ^ Emmanuel, FX (Dec 2007). "Human and animal infections with Mycobacterium microti, Scotland". Emerg Infect Dis. 13 (12): 1924–1927. doi:10.3201/eid1312.061536. PMC 2876740. PMID 18258049. Retrieved 26 August 2015.
- ^ van Soolingen, D (Jul 1998). "Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers". J Clin Microbiol. 36 (7): 1840–5. doi:10.1128/JCM.36.7.1840-1845.1998. PMC 104938. PMID 9650922.
- Reed, G. (1957). "Genus Mycobacterium (species affecting warm-blooded animals except those causing leprosy)". In Breed, R.S.; Murray, E.G.D.; Smith, N.R. (eds.). Bergey's Manual of Determinative Bacteriology (7th ed.). Baltimore: Williams & Wilkins. pp. 703–4.
- van Soolingen D, van der Zanden AG, de Haas PE, et al. (July 1998). "Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers". J. Clin. Microbiol. 36 (7): 1840–5. doi:10.1128/JCM.36.7.1840-1845.1998. PMC 104938. PMID 9650922.
- "Mycobacterium microti". NCBI Taxonomy Browser. 1806.
External links
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