BIRC7

BIRC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OXN, 1OXQ, 1OY7, 1TW6, 2I3H, 2I3I, 3F7G, 3F7H, 3F7I, 3GT9, 3GTA, 3UW5, 4AUQ
Identifiers
Aliases	BIRC7, KIAP, LIVIN, ML-IAP, MLIAP, RNF50, baculoviral IAP repeat containing 7
External IDs	OMIM: 605737; MGI: 2676458; HomoloGene: 51405; GeneCards: BIRC7; OMA:BIRC7 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.33 Start 63,235,883 bp End 63,240,495 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H4 Start 180,570,816 bp End 180,575,803 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve sural nerve placenta right adrenal cortex right lung gonad skin of leg skin of abdomen lymph node C1 segment Top expressed in lens epithelium of lens set of lens fibers ankle embryo dentate gyrus dentate gyrus of hippocampal formation granule cell cerebellar cortex primary visual cortex neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity cysteine-type endopeptidase inhibitor activity metal ion binding ubiquitin-protein transferase activity protein binding enzyme binding transferase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process ubiquitin protein ligase activity Cellular component cytoplasm Golgi apparatus nucleus microtubule organizing center cytosol Biological process negative regulation of peptidase activity inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process regulation of natural killer cell apoptotic process mitotic spindle assembly regulation of cell population proliferation regulation of signal transduction protein ubiquitination apoptotic process positive regulation of protein ubiquitination negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79444 329581 Ensembl ENSG00000101197 ENSMUSG00000038840 UniProt Q96CA5 A2AWP0 RefSeq (mRNA) NM_139317 NM_022161 NM_001163247 RefSeq (protein) NP_071444 NP_647478 NP_001156719 Location (UCSC) Chr 20: 63.24 – 63.24 Mb Chr 2: 180.57 – 180.58 Mb PubMed search
Wikidata
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Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.

External links

• Human BIRC7 genome location and BIRC7 gene details page in the UCSC Genome Browser.

Further reading

• Bavykin AS, Korotaeva AA, Poyarkov SV, et al. (2013). "Double siRNA-targeting of cIAP2 and LIVIN results in synergetic sensitization of HCT-116 cells to oxaliplatin treatment". OncoTargets Ther. 6 (6): 1333–40. doi:10.2147/OTT.S44893. PMC 3789649. PMID 24098083.
• Vucic D, Stennicke HR, Pisabarro MT, et al. (2001). "ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas". Curr. Biol. 10 (21): 1359–66. doi:10.1016/S0960-9822(00)00781-8. PMID 11084335. S2CID 10381671.
• Ashhab Y, Alian A, Polliack A, et al. (2001). "Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern". FEBS Lett. 495 (1–2): 56–60. doi:10.1016/S0014-5793(01)02366-3. PMID 11322947. S2CID 46380628.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Vucic D, Deshayes K, Ackerly H, et al. (2002). "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)". J. Biol. Chem. 277 (14): 12275–9. doi:10.1074/jbc.M112045200. PMID 11801603.
• Sanna MG, da Silva Correia J, Ducrey O, et al. (2002). "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition". Mol. Cell. Biol. 22 (6): 1754–66. doi:10.1128/MCB.22.6.1754-1766.2002. PMC 135597. PMID 11865055.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gazzaniga P, Gradilone A, Giuliani L, et al. (2003). "Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer". Ann. Oncol. 14 (1): 85–90. doi:10.1093/annonc/mdg002. PMID 12488298.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Crnkovic-Mertens I, Hoppe-Seyler F, Butz K (2004). "Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene". Oncogene. 22 (51): 8330–6. doi:10.1038/sj.onc.1206973. PMID 14614456. S2CID 21897515.
• Andersen MH, Reker S, Becker JC, thor Straten P (2004). "The melanoma inhibitor of apoptosis protein: a target for spontaneous cytotoxic T cell responses". J. Invest. Dermatol. 122 (2): 392–9. doi:10.1046/j.0022-202X.2004.22242.x. PMID 15009721.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tanabe H, Yagihashi A, Tsuji N, et al. (2005). "Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer". Lung Cancer. 46 (3): 299–304. doi:10.1016/j.lungcan.2004.05.002. PMID 15541814.
• Yagihashi A, Ohmura T, Asanuma K, et al. (2006). "Detection of autoantibodies to survivin and livin in sera from patients with breast cancer". Clin. Chim. Acta. 362 (1–2): 125–30. doi:10.1016/j.cccn.2005.06.009. PMID 16026775.
• Crnković-Mertens I, Semzow J, Hoppe-Seyler F, Butz K (2006). "Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells". J. Mol. Med. 84 (3): 232–40. doi:10.1007/s00109-005-0021-5. PMID 16437214. S2CID 28468027.
• Ma L, Huang Y, Song Z, et al. (2007). "Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway". Cell Death Differ. 13 (12): 2079–88. doi:10.1038/sj.cdd.4401959. PMID 16729033.
• Yan H, Brouha B, Liu T, et al. (2006). "Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase". J. Dermatol. Sci. 43 (3): 189–200. doi:10.1016/j.jdermsci.2006.05.007. PMC 2292408. PMID 16806840.
• Wu H, Ma Y, Zhu Y, et al. (2007). "Expression of BIRC7 protein and mRNA in non-Hodgkin's lymphoma". Leuk. Lymphoma. 47 (6): 1110–6. doi:10.1080/10428190500472271. PMID 16840203. S2CID 24671993.
• Crnković-Mertens I, Muley T, Meister M, et al. (2007). "The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells". Lung Cancer. 54 (2): 135–42. doi:10.1016/j.lungcan.2006.07.018. PMID 16965834.