Lipase member N

LIPN
Identifiers
Aliases	LIPN, ARCI8, LI4, LIPL4, bA186O14.3, lipase family member N
External IDs	OMIM: 613924; MGI: 1917416; HomoloGene: 66969; GeneCards: LIPN; OMA:LIPN - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	88,779,626 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,062,318 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of abdomen; ; blood; ; skin of leg; ; granulocyte; ; testicle; ; bone marrow; ; appendix; ; right lung; ; bone marrow cells;
	Top expressed in
	lumbar subsegment of spinal cord; ; lip; ; esophagus; ; zone of skin; ; vastus lateralis muscle; ; skin of abdomen; ; lumbar spinal ganglion; ; spleen; ; ear; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; hydrolase activity, acting on ester bonds; lipoprotein lipase activity; lipase activity;
Cellular component	extracellular region; intracellular membrane-bounded organelle;
Biological process	lipid catabolic process; lipid metabolism; cornification; cellular lipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	643418
	70166
	ENSG00000204020
	ENSMUSG00000024770
	Q5VXI9
	Q3U4B4
	NM_001102469
	NM_027340
	NP_001095939
	NP_081616
	Wikidata
View/Edit Human	View/Edit Mouse

Lipase family member N is a protein that in humans is encoded by the LIPN gene. ^[5]

Function

The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204020 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024770 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Lipase family member N". Retrieved 2019-12-02.

Function

References

Further reading