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LHX2

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LHX2
Identifiers
AliasesLHX2, LH2, hLhx2, LIM homeobox 2
External IDsOMIM: 603759; MGI: 96785; HomoloGene: 55848; GeneCards: LHX2; OMA:LHX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004789

NM_001290646
NM_010710

RefSeq (protein)

NP_004780

NP_001277575
NP_034840

Location (UCSC)Chr 9: 124 – 124.03 MbChr 2: 38.23 – 38.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[5][6][7]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]

Interactions

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LHX2 has been shown to interact with CITED2.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106689Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000247Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.
  6. ^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
  7. ^ a b "Entrez Gene: LHX2 LIM homeobox 2".
  8. ^ Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51). UNITED STATES: 36159–36167. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.

Further reading

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