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LCP1

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LCP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLCP1, CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1
External IDsOMIM: 153430; MGI: 104808; HomoloGene: 80174; GeneCards: LCP1; OMA:LCP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002298

NM_001247984
NM_008879

RefSeq (protein)

NP_002289
NP_002289.2

NP_001234913
NP_032905

Location (UCSC)Chr 13: 46.13 – 46.21 MbChr 14: 75.37 – 75.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.[5]

Function

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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136167Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021998Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (January 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry. 29 (4): 1055–62. doi:10.1021/bi00456a030. PMID 2111166.
  6. ^ "Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)".

Further reading

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