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Protein-coding gene in the species Homo sapiens
Pacer (also known as Rubicon-like) is a protein that in humans is encoded by the RUBCNL gene .[ 5] autophagy through regulation of PI3KC3 .[ 6]
Pacer contains a Rubicon homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage[ 7] [ 8] [ 9] Rubicon and PLEKHM1 .[ 10] autophagy .[ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000102445 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034959 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "RUBCNL - Protein associated with UVRAG as autophagy enhancer - Homo sapiens (Human) - RUBCNL gene & protein" . www.uniprot.org . Retrieved 2022-05-31 .^ Cheng X, Ma X, Ding X, Li L, Jiang X, Shen Z, et al. (March 2017). "Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17" . Molecular Cell . 65 (6): 1029–1043.e5. doi :10.1016/j.molcel.2017.02.010 PMID 28306502 . ^ Tudorica DA, Basak B, Puerta Cordova AS, Khuu G, Rose K, Lazarou M, et al. (July 2024). "A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy" . The Journal of Cell Biology . 223 (7). doi :10.1083/jcb.202309015 . PMC 11090050 PMID 38728007 . ^ "RUBCNL - Protein associated with UVRAG as autophagy enhancer - Homo sapiens (Human) - RUBCNL gene & protein" . www.uniprot.org . Retrieved 2022-05-31 .^ Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, et al. (July 2020). "Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex" . Proceedings of the National Academy of Sciences of the United States of America . 117 (29): 17003–17010. Bibcode :2020PNAS..11717003B . doi :10.1073/pnas.2008030117 PMC 7382272 PMID 32632011 . ^ a b Beltran S, Nassif M, Vicencio E, Arcos J, Labrador L, Cortes BI, et al. (March 2019). "Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis" . Molecular Neurodegeneration . 14 (1): 14. doi :10.1186/s13024-019-0313-9 PMC 6437924 PMID 30917850 .
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