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KLK1

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KLK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLK1, KLKR, Klk6, hK1, kallikrein 1
External IDsOMIM: 147910; MGI: 102850; HomoloGene: 110727; GeneCards: KLK1; OMA:KLK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002257

NM_010639
NM_001320331
NM_001320332

RefSeq (protein)

NP_002248

NP_001307260
NP_001307261
NP_034769

Location (UCSC)Chr 19: 50.82 – 50.82 MbChr 7: 43.87 – 43.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.[5][6][7] KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167748Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063903Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics. 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID 1684954.
  6. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  7. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
  8. ^ "Entrez Gene: KLK1 kallikrein 1".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: S01.160