Kelch-like protein 2

KLHL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XN4, 4CHB
Identifiers
Aliases	KLHL2, ABP-KELCH, MAV, MAYVEN, kelch like family member 2
External IDs	OMIM: 605774; MGI: 1924363; HomoloGene: 21416; GeneCards: KLHL2; OMA:KLHL2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	165,323,156 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	65,302,669 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; Region I of hippocampus proper; ; postcentral gyrus; ; optic nerve; ; external globus pallidus; ; superior frontal gyrus; ; middle temporal gyrus; ; dorsal motor nucleus of vagus nerve; ; Brodmann area 46; ; orbitofrontal cortex;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; dentate gyrus; ; subdivision of hippocampus; ; globus pallidus; ; Region I of hippocampus proper; ; primary motor cortex; ; hippocampus proper; ; piriform cortex; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; actin binding; identical protein binding;
Cellular component	ruffle; cell projection; actin cytoskeleton; lamellipodium; cytoskeleton; cytoplasm; Cul3-RING ubiquitin ligase complex; cytosol;
Biological process	protein ubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	11275
	77113
	ENSG00000109466
	ENSMUSG00000031605
	O95198
	Q8JZP3
	NM_001161521; NM_001161522; NM_007246; NM_001331023; NM_001331024
	NM_178633
	NP_001154993; NP_001154994; NP_001317952; NP_001317953; NP_009177
	NP_848748
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like family member 2 is a protein that in humans is encoded by the KLHL2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109466 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031605 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Kelch-like family member 2".

Tseng LA, Bixby JL (Aug 2011). "Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis". Molecular and Cellular Neurosciences. 47 (4): 254–64. doi:10.1016/j.mcn.2011.04.005. PMC 3137755. PMID 21549840.
Korutla L, Wang P, Jackson TG, Mackler SA (2009). "NAC1, a POZ/BTB protein that functions as a corepressor". Neurochemistry International. 54 (3–4): 245–52. doi:10.1016/j.neuint.2008.12.008. PMID 19121354. S2CID 23462562.
Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC (Sep 2005). "Role of Mayven, a kelch-related protein in oligodendrocyte process formation". Journal of Neuroscience Research. 81 (5): 622–31. doi:10.1002/jnr.20588. PMID 16035103. S2CID 31895360.
Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS (2013). "Update on the Kelch-like (KLHL) gene family". Human Genomics. 7 (1): 13. doi:10.1186/1479-7364-7-13. PMC 3658946. PMID 23676014.
Mai A, Jung SK, Yonehara S (Oct 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T (Jun 2014). "Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation". The Biochemical Journal. 460 (2): 237–46. doi:10.1042/BJ20140153. PMC 4019986. PMID 24641320.
Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S (Jul 1999). "Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain". Molecular Biology of the Cell. 10 (7): 2361–75. doi:10.1091/mbc.10.7.2361. PMC 25454. PMID 10397770.
Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S (Mar 2005). "Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells". Oncogene. 24 (14): 2398–409. doi:10.1038/sj.onc.1208466. PMID 15735724.
Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S (Aug 2013). "KLHL2 interacts with and ubiquitinates WNK kinases". Biochemical and Biophysical Research Communications. 437 (3): 457–62. doi:10.1016/j.bbrc.2013.06.104. PMID 23838290.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109466 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031605 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Kelch-like family member 2".

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References

Further reading