JPH4

JPH4
Identifiers
Aliases	JPH4, JP4, JPHL1, junctophilin 4
External IDs	MGI: 2443113; HomoloGene: 13034; GeneCards: JPH4; OMA:JPH4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,578,790 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,354,392 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; right hemisphere of cerebellum; ; right frontal lobe; ; nucleus accumbens; ; dorsolateral prefrontal cortex; ; temporal lobe; ; amygdala; ; primary visual cortex; ; anterior cingulate cortex; ; prefrontal cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; visual cortex; ; primary visual cortex; ; olfactory tubercle; ; hippocampus proper; ; nucleus accumbens; ; Region I of hippocampus proper; ; piriform cortex; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium-release channel activity;
Cellular component	dendritic shaft; integral component of membrane; plasma membrane; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; junctional sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; junctional membrane complex;
Biological process	regulation of ryanodine-sensitive calcium-release channel activity; calcium ion transport into cytosol; learning; neuromuscular process controlling balance; regulation of synaptic plasticity; regulation of cytokine production; regulation of store-operated calcium entry; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	84502
	319984
	ENSG00000092051
	ENSMUSG00000022208
	Q96JJ6
	Q80WT0
	NM_032452; NM_001146028
	NM_001003829; NM_177049
	NP_001139500; NP_115828
	NP_796023
	Wikidata
View/Edit Human	View/Edit Mouse

Junctophilin 4 is a protein in humans that is encoded by the JPH4 gene. ^[5]

This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092051 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022208 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Junctophilin 4". Retrieved 2013-04-13.

References

Further reading