Interposed nucleus
| Interposed nucleus | |
|---|---|
| Details | |
| Identifiers | |
| Latin | nucleus interpositus anterior, nucleus interpositus posterior |
| NeuroLex ID | nlx_anat_20081242 |
| Anatomical terms of neuroanatomy | |
The interposed nucleus is the combined paired globose and emboliform nuclei, (deep cerebellar nuclei) on either side of the cerebellum.[1][2] It is located in the roof of the fourth ventricle, lateral to the fastigial nucleus. The emboliform nucleus is the anterior interposed nucleus, and the globose nucleus is the posterior interposed nucleus.[3]
The interposed nucleus is responsible for coordinating agonist/antagonist muscle pairs, and therefore a lesion in this area causes tremor.
Anatomy
[edit]The interposed nucleus is located in the paravermis of the cerebellum.[citation needed]
The interposed nucleus is smaller than the dentate but larger than the fastigial nucleus.[citation needed]
Afferents
[edit]The interposed nuclei receives Purkine cell terminal afferents from the paravermal cortex of the spinocerebellum, as well as collaterals of cerebellar afferents from the restiform body and ventral spinocerebellar tract.[2]
It receives input from the ipsilateral posterior external arcuate fibers (cuneocerebellar tract) and the dorsal spinocerebellar tract, which originate in the accessory cuneate nucleus and the posterior thoracic nucleus, respectively.[citation needed]
Efferents
[edit]Afferents from the interposed nuclei leave the cerebellum through superior cerebellar peduncle. They project to:[2]
- contralateral (magnocellular division of) the red nucleus (→ rubrospinal tract). The red nucleus is the main target of tne interposed nuclei.
- ipsilateral ventral lateral nucleus of thalamus (→ premotor cortex and primary motor cortex → lateral corticospinal tract).
The rubrospinal and lateral corticospinal tracts are subsequently involved in control of the distal musculature of the extremities.
Function
[edit]The interposed nucleus modulates muscle stretch reflexes of proximal limb muscles, and is also required in delayed Pavlovian conditioning.[4]
References
[edit]- ^ Purves, Dale (2012). Neuroscience (5. ed.). Sunderland, Mass: Sinauer. p. 419. ISBN 9780878936953.
- ^ a b c Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 292. ISBN 978-1-118-67746-9.
- ^ Haines, Duane (2018). Fundamental neuroscience for basic and clinical applications (Fifth ed.). Philadelphia, PA: Elsevier. p. 396. ISBN 9780323396325.
- ^ Clark, Robert E.; Zhang, Andrew A.; Lavond, David G. (1992). "Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classically conditioned behavior". Behavioral Neuroscience. 106 (6): 879–888. doi:10.1037/0735-7044.106.6.879. PMID 1335267.
External links
[edit]- https://web.archive.org/web/20080405060224/http://www.lib.mcg.edu/edu/eshuphysio/program/section8/8ch6/s8ch6_30.htm
- http://www.neuroanatomy.wisc.edu/cere/text/P5/interp.htm
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