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INTS6

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INTS6
Identifiers
AliasesINTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDsOMIM: 604331; MGI: 1202397; HomoloGene: 8121; GeneCards: INTS6; OMA:INTS6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039937
NM_001039938
NM_001306091
NM_012141

NM_008715

RefSeq (protein)

NP_001035026
NP_001035027
NP_001293020
NP_036273

NP_032741

Location (UCSC)Chr 13: 51.35 – 51.45 MbChr 14: 62.91 – 63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.[5][6][7]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102786Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035161Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.
  6. ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
  7. ^ a b "Entrez Gene: INTS6 integrator complex subunit 6".

Further reading

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