Interferon-induced transmembrane protein 2

IFITM2
Identifiers
Aliases	IFITM2, 1-8D, DSPA2c, interferon induced transmembrane protein 2
External IDs	OMIM: 605578; MGI: 1933382; HomoloGene: 74574; GeneCards: IFITM2; OMA:IFITM2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	309,397 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,535,900 bp
RNA expression pattern
	Top expressed in
	blood; ; right lung; ; pericardium; ; periodontal fiber; ; spleen; ; upper lobe of left lung; ; left uterine tube; ; Descending thoracic aorta; ; olfactory bulb; ; granulocyte;
	Top expressed in
	adrenal gland; ; granulocyte; ; uterus; ; lung; ; urinary bladder; ; lip; ; white adipose tissue; ; zone of skin; ; heart; ; epiblast;
	More reference expression data
	n/a
Orthologs
	10581
	80876
	ENSG00000185201
	ENSMUSG00000060591
	Q01629
	Q99J93
	NM_006435
	NM_030694
	NP_006426
	NP_109619
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene.^[5] IFITM1 is a member of the IFITM family (Interferon-induced transmembrane protein) which is encoded by IFITM genes.

As the name implies, these genes are induced by interferon and form part of its signaling pathway. In the absence of interferon stimulation, IFITM proteins can express broadly in tissues and cell lines. In humans, IFITM1, IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts.^[6]

Antiviral function

IFITM proteins have been identified as antiviral restriction factors that block the early stages of viral replication.^[7] They inhibit influenza A virus replication,^[8] and infection with a wide range of other enveloped viruses^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185201 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060591 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Interferon induced transmembrane protein 2". Retrieved 2016-02-21.
^ Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (December 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev. Cell. 9 (6): 745–56. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.
^ Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL (January 2013). "IFITM proteins restrict viral membrane hemifusion". PLOS Pathog. 9 (1): e1003124. doi:10.1371/journal.ppat.1003124. PMC 3554583. PMID 23358889.
^ Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL (October 2011). "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry". PLOS Pathog. 7 (10): e1002337. doi:10.1371/journal.ppat.1002337. PMC 3203188. PMID 22046135.
^ Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ (December 2009). "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus". Cell. 139 (7): 1243–54. doi:10.1016/j.cell.2009.12.017. PMC 2824905. PMID 20064371.

Antiviral function

References

Further reading