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HIST2H4A

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H4C14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH4C14, FO108, H4, H4/n, H4F2, H4FN, HIST2H4, histone cluster 2, H4a, histone cluster 2 H4 family member a, HIST2H4A, H4 clustered histone 14, H4C4, H4C9, H4C3, H4C1, H4C13, H4C11, H4C8, H4C5, H4C12, H4C15, H4C2, H4-16, H4C6
External IDsOMIM: 142750; MGI: 2448420; HomoloGene: 134466; GeneCards: H4C14; OMA:H4C14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003548

NM_178193

RefSeq (protein)
Location (UCSC)Chr 1: 149.83 – 149.84 MbChr 13: 23.94 – 23.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST2H4A gene.[5][6][7][8]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000270882Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069266Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pauli U, Chrysogelos S, Stein G, Stein J, Nick H (Jul 1987). "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene". Science. 236 (4806): 1308–11. Bibcode:1987Sci...236.1308P. doi:10.1126/science.3035717. PMID 3035717.
  6. ^ Sierra F, Stein G, Stein J (Dec 1983). "Structure and in vitro transcription of a human H4 histone gene". Nucleic Acids Res. 11 (20): 7069–86. doi:10.1093/nar/11.20.7069. PMC 326439. PMID 6314274.
  7. ^ Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS (Nov 2004). "Functional characterization of a human histone gene cluster duplication". Gene. 342 (1): 35–40. doi:10.1016/j.gene.2004.07.036. PMID 15527963.
  8. ^ a b "Entrez Gene: HIST2H4A histone cluster 2, H4a".

Further reading

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