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HIF1AN

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HIF1AN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHIF1AN, FIH1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, HIFAN
External IDsOMIM: 606615; MGI: 2442345; HomoloGene: 9906; GeneCards: HIF1AN; OMA:HIF1AN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017902

NM_176958

RefSeq (protein)

NP_060372

NP_795932

Location (UCSC)Chr 10: 100.53 – 100.56 MbChr 19: 44.55 – 44.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene.[5][6]

Interactions

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FIH has been shown to interact with HIF1A[5] and Von Hippel-Lindau tumor suppressor.[5] Additionally, asparaginyl hydroxylation of HIF1α by FIH-1 (HIF1AN) at N803 impairs its interaction with CBP/P300.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166135Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036450Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Mahon PC, Hirota K, Semenza GL (Oct 2001). "FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity". Genes Dev. 15 (20): 2675–86. doi:10.1101/gad.924501. PMC 312814. PMID 11641274.
  6. ^ "Entrez Gene: HIF1AN hypoxia-inducible factor 1, alpha subunit inhibitor".
  7. ^ Chen C, Lou T (2017). "Hypoxia inducible factors in hepatocellular carcinoma". Oncotarget. 8 (28): 46691–703. doi:10.18632/oncotarget.17358. PMC 5542303. PMID 28493839.

Further reading

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