Guanylate cyclase activator

A guanylate cyclase activator (or "GUCA") is a member of a group of proteins that upregulate guanylate cyclase. GUCA is also known as guanylate cyclase-activating protein (or "GCAP"). Its mutations can be associated with vision defects.^[1]

There are five genes involved:

GUCA1A, GUCA1B, GUCA1C
GUCA2A, GUCA2B

There are several therapeutic drugs that act as GUCAs, including linaclotide and plecanatide, which are guanylate cyclase-C receptor agonists. These drugs increase the secretion of bicarbonate and chloride in the colon and potentially relieve visceral hypersensitivity in IBS-C patients.^[2]

References

^ Payne AM, Downes SM, Bessant DA, et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. doi:10.1093/hmg/7.2.273. PMID 9425234.
^ Saps, Miguel; Miranda, Adrian (2017), Greenwood-Van Meerveld, Beverley (ed.), "Gastrointestinal Pharmacology", Gastrointestinal Pharmacology, vol. 239, Cham: Springer International Publishing, pp. 147–176, doi:10.1007/164_2016_119, ISBN 978-3-319-56359-6, retrieved 2024-04-27

External links

Guanylate+Cyclase-Activating+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid94252343-1] Payne AM, Downes SM, Bessant DA, et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. doi:10.1093/hmg/7.2.273. PMID 9425234.

[2] Saps, Miguel; Miranda, Adrian (2017), Greenwood-Van Meerveld, Beverley (ed.), "Gastrointestinal Pharmacology", Gastrointestinal Pharmacology, vol. 239, Cham: Springer International Publishing, pp. 147–176, doi:10.1007/164_2016_119, ISBN 978-3-319-56359-6, retrieved 2024-04-27

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