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GPS1

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GPS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGPS1, COPS1, CSN1, SGN1, G protein pathway suppressor 1
External IDsOMIM: 601934; MGI: 2384801; HomoloGene: 3046; GeneCards: GPS1; OMA:GPS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177874
NM_145370
NM_001346709
NM_001363440

RefSeq (protein)

n/a

Location (UCSC)Chr 17: 82.05 – 82.06 MbChr 11: 120.68 – 120.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

COP9 signalosome complex subunit 1 is a protein that in humans is encoded by the GPS1 gene.[5][6]

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169727Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025156Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.
  6. ^ a b "Entrez Gene: GPS1 G protein pathway suppressor 1".

Further reading

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