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GOLGA1

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GOLGA1
Identifiers
AliasesGOLGA1, golgin-97, golgin A1
External IDsOMIM: 602502; MGI: 1924149; HomoloGene: 68223; GeneCards: GOLGA1; OMA:GOLGA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002077

NM_001290649
NM_029793

RefSeq (protein)

NP_002068

NP_001277578
NP_084069

Location (UCSC)Chr 9: 124.88 – 124.95 MbChr 2: 38.91 – 38.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.[5][6]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein is associated with Sjogren's syndrome.[6]

Interactions

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GOLGA1 has been shown to interact with ARL1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136935Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026754Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Griffith KJ, Chan EK, Lung CC, Hamel JC, Guo X, Miyachi K, Fritzler MJ (September 1997). "Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome". Arthritis and Rheumatism. 40 (9): 1693–1702. doi:10.1002/art.1780400920. PMID 9324025.
  6. ^ a b "Entrez Gene: GOLGA1 golgi autoantigen, golgin subfamily a, 1".
  7. ^ Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9): 3767–3781. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.

Further reading

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