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GNPDA2

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GNPDA2
Identifiers
AliasesGNPDA2, GNP2, SB52, glucosamine-6-phosphate deaminase 2
External IDsOMIM: 613222; MGI: 1915230; HomoloGene: 12381; GeneCards: GNPDA2; OMA:GNPDA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270880
NM_001270881
NM_138335

NM_001038015
NM_027681
NM_001347363
NM_001359239

RefSeq (protein)

NP_001257809
NP_001257810
NP_612208

NP_001033104
NP_001334292
NP_001346168

Location (UCSC)Chr 4: 44.68 – 44.73 MbChr 5: 69.73 – 69.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucosamine-6-phosphate deaminase 2 also known as GNPDA2 is an enzyme that in humans is encoded by the GNPDA2 gene.[5]

Clinical significance

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Variants of the GNPDA2 gene may be associated with obesity.[6][7][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163281Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029209Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Arreola R, Valderrama B, Morante ML, Horjales E (September 2003). "Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study". FEBS Lett. 551 (1–3): 63–70. doi:10.1016/S0014-5793(03)00896-2. PMID 12965206. S2CID 45050024.
  6. ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790.
  7. ^ Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.
  8. ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 25–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.

Further reading

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