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GMEB2

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GMEB2
Identifiers
AliasesGMEB2, P79PIF, PIF79, GMEB-2, glucocorticoid modulatory element binding protein 2
External IDsOMIM: 607451; MGI: 2652836; HomoloGene: 8228; GeneCards: GMEB2; OMA:GMEB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012384

NM_198169

RefSeq (protein)

NP_036516

NP_937812

Location (UCSC)Chr 20: 63.59 – 63.63 MbChr 2: 180.89 – 180.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene.[5][6][7]

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101216Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038705Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC 84824. PMID 10523663.
  6. ^ Burnett E, Christensen J, Tattersall P (Dec 2001). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID 11743720.
  7. ^ a b "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2".

Further reading

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