Jump to content

GCNT1

From Wikipedia, the free encyclopedia
(Redirected from GCNT1 (gene))
GCNT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGCNT1, C2GNT, C2GNT-L, C2GNT1, G6NT, NACGT2, NAGCT2, glucosaminyl (N-acetyl) transferase 1, core 2, glucosaminyl (N-acetyl) transferase 1
External IDsOMIM: 600391; MGI: 95676; HomoloGene: 37486; GeneCards: GCNT1; OMA:GCNT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001097633
NM_001097634
NM_001097635
NM_001097636
NM_001490

NM_001136484
NM_010265
NM_173442

RefSeq (protein)

NP_001091102
NP_001091103
NP_001091104
NP_001091105
NP_001481

NP_001129956
NP_034395
NP_775618

Location (UCSC)Chr 9: 76.42 – 76.65 MbChr 19: 17.3 – 17.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.[5][6][7]

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187210Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038843Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bierhuizen MF, Mattei MG, Fukuda M (Apr 1993). "Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family". Genes Dev. 7 (3): 468–78. doi:10.1101/gad.7.3.468. PMID 8449405.
  6. ^ Yeh JC, Ong E, Fukuda M (Mar 1999). "Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches". J Biol Chem. 274 (5): 3215–21. doi:10.1074/jbc.274.5.3215. PMID 9915862.
  7. ^ a b "Entrez Gene: GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)".

Further reading

[edit]