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GBGT1

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GBGT1
Identifiers
AliasesGBGT1, A3GALNT, FS, UNQ2513, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
External IDsOMIM: 606074; MGI: 2449143; HomoloGene: 110677; GeneCards: GBGT1; OMA:GBGT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021996
NM_001282629
NM_001282632
NM_001288572
NM_001288573

NM_139197

RefSeq (protein)

NP_001269558
NP_001269561
NP_001275501
NP_001275502
NP_068836

NP_631936

Location (UCSC)Chr 9: 133.15 – 133.16 MbChr 2: 28.39 – 28.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GBGT1 gene.[5][6][7]

This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148288Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026829Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu H, Storch T, Yu M, Elliott SP, Haslam DB (October 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". The Journal of Biological Chemistry. 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID 10506200.
  6. ^ Haslam DB, Baenziger JU (October 1996). "Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 10697–702. Bibcode:1996PNAS...9310697H. doi:10.1073/pnas.93.20.10697. PMC 38217. PMID 8855242.
  7. ^ a b "Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1".

Further reading

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