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GAS2

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GAS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGAS2, growth arrest specific 2, GAS-2
External IDsOMIM: 602835; MGI: 95657; HomoloGene: 31301; GeneCards: GAS2; OMA:GAS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008087
NM_001330607
NM_001330608

RefSeq (protein)

NP_001137302
NP_005247
NP_808221
NP_001338153

NP_001317536
NP_001317537
NP_032113

Location (UCSC)Chr 11: 22.63 – 22.81 MbChr 7: 51.51 – 51.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.[5][6]

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148935Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030498Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.
  6. ^ a b "Entrez Gene: GAS2 growth arrest-specific 2".

Further reading

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