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GANC

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GANC
Identifiers
AliasesGANC, glucosidase alpha, neutral C
External IDsOMIM: 104180; MGI: 1923301; HomoloGene: 25627; GeneCards: GANC; OMA:GANC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198141
NM_001301409
NM_001301410

NM_172672

RefSeq (protein)

NP_001288338
NP_001288339
NP_937784

NP_766260

Location (UCSC)Chr 15: 42.27 – 42.36 MbChr 2: 120.23 – 120.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene.[5][6][7]

Function

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Glycoside hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214013Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062646Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15". Cytogenetics and Cell Genetics. 27 (2–3): 168–75. doi:10.1159/000131478. PMID 6995030.
  6. ^ Hirschhorn R, Huie ML, Kasper JS (Oct 2002). "Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13642–6. Bibcode:2002PNAS...9913642H. doi:10.1073/pnas.202383599. PMC 129728. PMID 12370436.
  7. ^ a b "Entrez Gene: GANC glucosidase, alpha; neutral C".

Further reading

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