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GABRP

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GABRP
Identifiers
AliasesGABRP, gamma-aminobutyric acid type A receptor pi subunit, gamma-aminobutyric acid type A receptor subunit pi
External IDsOMIM: 602729; MGI: 2387597; HomoloGene: 22798; GeneCards: GABRP; OMA:GABRP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291985
NM_014211

NM_146017

RefSeq (protein)

NP_001278914
NP_055026

NP_666129

Location (UCSC)Chr 5: 170.76 – 170.81 MbChr 11: 33.5 – 33.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.[5][6]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000094755Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020159Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hedblom E, Kirkness EF (Jul 1997). "A novel class of GABAA receptor subunit in tissues of the reproductive system". J Biol Chem. 272 (24): 15346–15350. doi:10.1074/jbc.272.24.15346. PMID 9182563.
  6. ^ a b "Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.