DescriptionVirus Replication large.svg	A diagram of influenza viral cell invasion and replication.
Date	5 March 2007
Source	Scaled up from Image:Virus Replication.svg by User:YK Times, who redrew from w:Image:Virusreplication.png using Adobe Illustrator. Based on Scheme of Influenza A virus replication, NCBI, artwork by David Hobson, August 6, 2002
Author	User:YK Times
Permission (Reusing this file)	I, the copyright holder of this work, hereby publish it under the following licenses: Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.http://www.gnu.org/copyleft/fdl.htmlGFDLGNU Free Documentation Licensetruetrue This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. You are free: to share – to copy, distribute and transmit the work to remix – to adapt the work Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original. This licensing tag was added to this file as part of the GFDL licensing update.http://creativecommons.org/licenses/by-sa/3.0/CC BY-SA 3.0Creative Commons Attribution-Share Alike 3.0truetrue This file is licensed under the Creative Commons Attribution-Share Alike 2.5 Generic, 2.0 Generic and 1.0 Generic license. You are free: to share – to copy, distribute and transmit the work to remix – to adapt the work Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original. https://creativecommons.org/licenses/by-sa/2.5CC BY-SA 2.5 Creative Commons Attribution-Share Alike 2.5 truetrue You may select the license of your choice.
Other versions	Armenian Original small version Spanish version Simp. Chinese version Trad. Chinese version

From Scheme of Influenza A virus replication (NCBI):

"A virion attaches to the host cell membrane using Hemagglutinin(HA) and enters the cytoplasm by receptor-mediated endocytosis (STEP 1), thereby forming an endosome. A cellular trypsin-like enzyme cleaves HA into products HA1 and HA2 (not shown). HA2 promotes fusion of the virus envelope and the endosome membranes. A minor virus envelope protein M2 acts as a ion channel making the inside of the virion more acidic. As a result, the major envelope protein M1 dissociates from the nucleocapsid and vRNAs are translocated into the nucleus (STEP 2) via interaction between NP and cellular transport machinery. In the nucleus, the viral polymerase complexes transcribe (STEP 3a) and replicate (STEP 3b) the vRNAs. Newly synthesized mRNAs migrate to cytoplasm (STEP 4) where they are translated. Posttranslational processing of HA, Neuraminidase(NA), and M2 includes transportation via Golgi apparatus to the cell membrane (STEP 5b). NP, M1, NS1 (nonstructural regulatory protein - not shown) and NEP (nuclear export protein, a minor virion component - not shown) move to the nucleus (STEP 5a) and bind freshly synthesized copies of vRNAs. The newly formed nucleocapsids migrate into the cytoplasm in a NEP-dependent process and eventually interact via protein M1 with a region of the cell membrane where HA, NA and M2 have been inserted (STEP 6). Then the newly synthesized virions bud from infected cell (STEP 7). NA destroys the sialic acid moiety of cellular receptors, thereby releasing the progeny virions.