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File:Vasculitic neuropathy - plastics - intermed mag.jpg

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Summary

Description
English: Intermediate magnification micrograph of a vasculitic neuropathy, also neuropathy due to a vasculitis. Resin section (plastics) with toluidine blue stain.

The pathologic features of vasculitic neuropathy are evident:

  • Zonal involvement of the nerve fascicles with:
    • Loss of myelin.
    • Wallerian degeneration.
    • Regeneration.

Chronic active vasculitis:

  • Active features:
    • Perivascular and mural inflammatory infiltrate including lymphocytes and histiocytes.
    • Plump (reactive) endothelial cells.
    • Vessel wall cell death (necrosis).
  • Chronic features:
    • Vessel wall thickening due to hyperplasia.
    • Dense fibrous tissue around the vessel.

The vasculitis in this case affects both small (< 100 micrometers) and medium vessels. Granulomas are absent. Eosinophils are rare. Histomorphologic, diagnostic considerations are polyarteritis nodosa and microscopic polyangiitis.

  • Low mag.
    Low mag.
  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.
  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.
  • Very high mag.
    Very high mag.
Source Own work
Author Nephron

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current04:14, 26 July 2011Thumbnail for version as of 04:14, 26 July 20114,272 × 2,848 (4.71 MB)Nephron{{Information |Description ={{en|1=Intermediate magnification micrograph of a '''vasculitic neuropathy''', also '''neuropathy due to a vasculitis'''. Resin section (plastics) with [[w:toluidine blue st

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