File:Type II topoisomerase catalytic cycle.png
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Summary
| Description |
English: Type II topoisomerase strand-passage mechanism. (1) G-segment is bound at the DNA-gate and the T-segment is captured. (2) ATP binding stimulates dimerization of the N-gate, the G-segment is cleaved and the T-segment is passed through the break. (3) The G-segment is re-ligated and the T-segment exits through the C-gate. For type IIB topos, there is no C-gate so once the T-segment passes through the G-segment, it is released from the enzyme. (4) Dissociation of ADP and Pi allows N-gate opening, a scenario where the enzyme either remains bound to the G-segment, ready to capture a successive T-segment, or (5) dissociates from the G-segment. |
| Date | |
| Source | Own work |
| Author | Kcneuman |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 05:42, 22 June 2022 | | 3,341 × 2,864 (1.62 MB) | Kcneuman | corrected a spelling mistake on the image |
| 06:29, 10 April 2022 |  | 3,340 × 2,864 (1.89 MB) | Kcneuman | Uploaded own work with UploadWizard |
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