English: A multiple sequence alignment of TMEM89 orthologs found within multiple mammal species. Labels: Sarc_TMEM89, Sarcophilus harrisii (Tasmanian devil); Tric_TMEM89, Trichosurus vulpeca (Common brushtail possum); Mani_TMEM89, Manis pentadactyla (Chinese pangolin); ManiJ_TMEM89, Manis javanica (Malayan pangolin); Dasy_TMEM89, Dasypus novemcinctus (Nine-banded armadillo); Afer_TMEM89, Orycteropus afer afer (Aardvark); Loxo_TMEM89, Loxodonta africana (African bush elephant); Homo_TMEM89, Homo sapiens (Human); Talp_TMEM89, Talpa occidentalis (Spanish mole); Condy_TMEM89, Condylura cristata (Star-nosed mole); Uroc_TMEM89, Urocitellus parryii (Arctic ground squirrel); Cast_TMEM89, Castor canadensis (American beaver); Pter_TMEM89, Pteropus alecto (Black flying fox); Des_TMEM89, Desmodus rotundus (Common vampire bat); Cera_TMEM89, Ceratotherium simum simum (Southern white rhinoceros); Taurus_TMEM89, Bos taurus (Cow); Orca_TMEM89, Orca orcinus (Orca); Canis_TMEM89, Canis lupus familiaris (Dog), Odob_TMEM89, Odobenus rosmarus divergens (Pacific walrus). Letter colors correspond to different amino acid chemical properties: pink, positive charge; red, hydrophobic; blue, negative charge; green, hydrophilic. Asterisks mean an exact amino acid is conserved at that position in all the sequences. Two dots mean very similar amino acids are conserved at that position in all the sequences. One dot means similar amino acids are conserved at that position in all sequences. Important features of the sequences are highlighted and/or boxed: Black box, Human TMEM_89 signal sequence; yellow box, most conserved region; green box, Human TMEM89 exon boundary; purple box, second most conserved region; pink highlight, Human TMEM89 extracellular domain; blue highlight, Human TMEM89 transmembrane domain; orange highlight, Human TMEM89 cytoplasmic domain. The number of amino acids in each line is to the right. The sequences used were found using Protein BLAST on NCBI. Multiple sequence alignment made with Clustal Omega.
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