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Summary

Description
English: Visualization of squamous cell carcinoma with Pafolacianine (OTL38) that binds folate receptor alpha. From the research paper: Figure 1. Pulmonary SCCs display in situ fluorescence during FR-IMI with OTL38. Representative example: Subject 3 presented with a 1.7cm left upper lobe nodule by preoperative CT (a). Preoperative PET displayed an SUV of 8.7 (b). During FR-IMI the nodule was localized during standard thoracoscopic views (c), and displayed strong NIR signal during fluorescent imaging (d). Median fluorescent intensity (MFI) was determined for ROIs corresponding to tumor (e) and benign lung (background) (f). MFIs for ROIs were compared for SCCs (n=7) displaying in situ signal (g). Red circle-pulmonary SCC; yellow gates-ROIs measured by fluorescent analysis; ***p<0.001.
Русский: Визуализация плоскоклеточной карциномы в ходе операции с помощью пафолацианина, связывающего фолатный рецептор альфа.
Date
Source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862595/
Author Jarrod D. Predina, Andrew D. Newton, Leilei Xia, Christopher Corbett, Courtney Connolly, Michael Shin, Lydia Frezel Sulyok, Leslie Litzky, Charuhas Deshpande, Shuming Nie, Sumith A. Kularatne, Philip S. Low, and Sunil Singhal

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Visualization of squamous cell carcinoma with Pafolacianine (OTL38) that binds folate receptor alpha

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2 January 2018

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current14:44, 15 May 2022Thumbnail for version as of 14:44, 15 May 2022720 × 582 (132 KB)CopperKettleUploaded a work by Jarrod D. Predina, Andrew D. Newton, Leilei Xia, Christopher Corbett, Courtney Connolly, Michael Shin, Lydia Frezel Sulyok, Leslie Litzky, Charuhas Deshpande, Shuming Nie, Sumith A. Kularatne, Philip S. Low, and Sunil Singhal from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862595/ with UploadWizard

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