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File:Sickle Cell Anemia and its Protection Against Malaria.svg

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English: In series A the red blood cell becomes sickled after interaction with the malarial merozoite, which then begins to multiply in the cell (schizont). Due to the heterozygous nature of the cell, and the hemoglobin inside it causing sickling, likely as a result of the lowering of the pH and deoxygenation, the cell can be targeted and eliminated by macrophages before the infection can reproduce, lowering the overall amount of infected cells in comparison to normal red blood cells. In series B the normal red blood cell becomes infected by the merozoite, which multiplies inside the cell, eventually causing hemolysis of the cell, and the offspring go on to infect other cells.
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Author Dsheffer02

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Captions

Possible advantage of being heterozygous for sickle cell anemia disease (A) vs. normal blood cell response (B) when infected with malaria.

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12 June 2019

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current14:10, 12 June 2019Thumbnail for version as of 14:10, 12 June 2019512 × 311 (159 KB)Dsheffer02User created page with UploadWizard

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