File:Replication stress and its consequences in mitosis.png
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Summary
| Description |
English: Replication stress from either endogenous or exogenous causes (red circles) leaves chromosomal segment unreplicated or interwinded leading to anaphase bridges formation. Single-ended DSB could lead to dicentric chromosome formation and thus, also, to anaphase bridge formation. Non-detected damages upon low replicative stress could be grouped in one detectable entity in G1: 53BP1 bodies and/or micronuclei. Replication stress also favors mitotic extra centrosomes and multipolar mitosis, thus amplifying mitotic catastrophes and genome instability to the whole genome.[1] |
| Date | |
| Source | https://doi.org/10.3390/genes6020267 |
| Author | Camille Gelot, Indiana Magdalou, and Bernard S. Lopez |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 23:05, 24 May 2020 | | 2,200 × 3,200 (2.48 MB) | Rob Hurt | Uploaded a work by Camille Gelot, Indiana Magdalou, and Bernard S. Lopez from https://doi.org/10.3390/genes6020267 with UploadWizard |
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