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File:Rainplot for Kataegis in Breast Cancer Genome.jpg

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Summary

Description
English: Rainplot maps the intermutational distance of breast cancer genes and tracks the basepair substitution in each mutation. The dots at the lower half of the graph show mutations that are close to each other and cluster together, known as kataegis in this case. We can see that most mutation in kataegis are consist of C→T substitution. From A) we see kataegis in a smaller region, and in B) kataegis is all over the genome. Data are originally from the Breast Cancer Working Group of the International Cancer Genome Consortium.
Date
Source https://ars.els-cdn.com/content/image/1-s2.0-S0092867412005284-gr3_lrg.jpg
Author Serena Nik-Zainal, Ludmil B.Alexandrov, David C.Wedge, Peter Van Loo, Christopher D.Greenman, Keiran Raine, David Jones, Jonathan Hinton, John Marshall, Lucy A.Stebbings, Andrew Menzies, Sancha Martin, Kenric Leung, Lina Chen, Catherine Leroy, Manasa Ramakrishna, Richard Rance, King Wai Lau, Laura J.Mudie, Ignacio Varela, David J.McBride, Graham R.Bignell, Susanna L.Cooke, Adam Shlien, John Gamble, Ian Whitmore, Mark Maddison, Patrick S.Tarpey, Helen R.Davies, Elli Papaemmanuil, Philip J.Stephens, Stuart McLaren, Adam P.Butler, Jon W.Teague, Göran Jönsson, Judy E.Garber, Daniel Silver, Penelope Miron, Aquila Fatima, Sandrine Boyault, Anita Langerød, Andrew Tutt, John W.M.Martens, Samuel A.J.R.Aparicio, Åke Borg, Anne Vincent Salomon, Gilles Thomas, Anne-Lise Børresen-Dale, Andrea L.Richardson, Michael S.Neuberger, P. Andrew Futreal, Peter J.Campbell, Michael R.Stratton

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Captions

The red dots at the lower half of the graph show A) kataegis clustered in a smaller region, and B)kataegis all over the genome.

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17 May 2012

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1,878 pixel

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