File:RMB4 action in Pancreas.jpg
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Summary
| Description |
English: The general framework for a gene expression and signaling circuit in the pancreas is regulated by RBM4. RBM4 influences alternative splicing of various pancreatic factors, such as Isl1, Pax4, and IR. The isoforms of Isl1 and Pax4 induced by RBM4 have the potential to enhance insulin gene transcription. Additionally, the IR-B isoform induced by RBM4 likely demonstrates increased signaling activity upon insulin binding, leading to elevated glucose uptake and signaling (represented by the dashed line). |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554116/ |
| Author | Jung-Chun Lin, Yu-Ting Yan, Wen-Kou Hsieh, Pey-Jey Peng, Chun-Hao Su, and Woan-Yuh Tarn |
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This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:26, 28 November 2023 | | 500 × 1,027 (46 KB) | Biochem.Madison | Uploaded a work by Jung-Chun Lin, Yu-Ting Yan, Wen-Kou Hsieh, Pey-Jey Peng, Chun-Hao Su, and Woan-Yuh Tarn from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554116/ with UploadWizard |
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