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Summary

Description The structure of neprilysin, a zinc metalloprotease involved in the metabolism of extracellular regulatory peptides such as the enkephalins and substance P. Neprilysin in neural tissue is the major protease degrading amyloid beta, a peptide fragment whose abnormal misfolding and aggregation is associated with Alzheimer's disease. The gray sphere represents a zinc atom; the green structure is a zinc-chelating enzyme inhibitor.
Date
Source Self-created from PDB ID 1R1H using PyMol
Author Opabinia regalis
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(Reusing this file)		 GFDL

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inception

7 March 2007

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Date/TimeThumbnailDimensionsUserComment
current02:41, 8 March 2007Thumbnail for version as of 02:41, 8 March 20071,086 × 814 (501 KB)Opabinia regaliswrong version, forgot to crop
02:39, 8 March 2007Thumbnail for version as of 02:39, 8 March 20071,700 × 1,118 (530 KB)Opabinia regalis{{Information |Description=The structure of neprilysin, a zinc metalloprotease involved in the metabolism of extracellular regulatory peptides such as the enkephalins and substance P. Neprilysin in neural tissue is the major protease degrading amyloid bet

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