File:Muscle protein synthesis signaling cascades.jpg
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Summary
| Description |
English: Diagram of the molecular signaling cascades that are involved in myofibrillar muscle protein synthesis and mitochondrial biogenesis in response to physical exercise and specific amino acids or their derivatives (primarily leucine and beta-hydroxy beta-methylbutyrate).
Abbreviations and schematic representations: ■PLD: phospholipase D■PA: phosphatidic acid ■mTOR: mechanistic target of rapamycin ■AMP: adenosine monophosphate ■ATP: adenosine triphosphate ■AMPK: AMP-activated protein kinase ■PGC‐1α: peroxisome proliferator-activated receptor gamma coactivator-1α ■4EBP1: eukaryotic translation initiation factor 4E-binding protein 1 ■S6K1: p70S6 kinase ■eIF4E: eukaryotic translation initiation factor 4E ■RPS6: ribosomal protein S6 ■eEF2: eukaryotic elongation factor 2 ■RE: resistance exercise; EE: endurance exercise ■Myo: myofibrillar; Mito: mitochondrial ■AA: amino acids ■↑ represents activation ■Τ represents inhibition |
| Date | |
| Source | (January 2016). "Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise". Acta Physiol (Oxf) 216 (1): 15–41. DOI:10.1111/apha.12532. PMID 26010896. PMC: 4843955. Figure 1 |
| Author | Brook MS, Wilkinson DJ, Phillips BE, Perez-Schindler J, Philp A, Smith K, Atherton PJ |
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 06:11, 3 September 2016 | | 619 × 347 (75 KB) | Seppi333 | change AA to "AA or HMB" |
| 02:47, 2 September 2016 |  | 619 × 347 (75 KB) | Seppi333 | Reverted to version as of 02:21, 22 July 2016 (UTC) | |
| 12:30, 1 September 2016 |  | 619 × 347 (75 KB) | Seppi333 | changed amino acids to "Leucine or HMB" | |
| 02:21, 22 July 2016 |  | 619 × 347 (75 KB) | Seppi333 | Fixed an error in the original diagram. The "AMP:ATP" text should have had an up-arrow next to it since a high AMP:ATP ratio activates AMPK. | |
| 21:34, 23 May 2016 |  | 619 × 347 (64 KB) | Seppi333 | User created page with UploadWizard |
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