DescriptionModulating Enamine Nucleophilicity via Stereoelectronicand Inductive Effects.png
English: Donation of the N lone pair into the C-C double bond produces a significant effect on the overall nucleophilicity of the system. Inductive effects of the ring oxygens encourage N pyramidalization which causes it to lose co-planrity with the C-C bond, eliminating that ineraction and thus reducing the nucleophilicity of that bond.
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