File:Laron syndrome 01.jpg
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| Description |
English: Impact of insulin/IGF-1 signaling in Laron syndrome (A) and Western diet (B) on FoxO-mediated gene regulation and associated pathologies. GHR*, growth hormone receptor loss of function mutation in Laron syndrome; GIP, glucose-dependent insulinotropic polypeptide, a whey protein-induced incretin, which stimulates β-cell proliferation and insulin secretion; PRL, prolactin; PRL secretion is induced by serotoninergic hypothalamic signaling; Trp, tryptophan, and Leu, leucine, essential amino acids enriched in the whey protein α-lactalbumin; Trp via serotonin synthesis stimulates pituitary GH and PRL secretion and Leu stimulates β-cell proliferation and insulin secretion. |
| Date | published 24 June 2011 |
| Source | B. C. Melnik, S. M. John, G. Schmitz: Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome. In: Nutrition & metabolism Band 8, 2011, p. 41, ISSN 1743-7075. doi:10.1186/1743-7075-8-41. PMID 21699736. |
| Author | B. C. Melnik, S. M. John, G. Schmitz |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:45, 20 July 2011 | | 1,109 × 812 (245 KB) | Kuebi | {{Information |Description={{en|Impact of insulin/IGF-1 signaling in Laron syndrome (A) and Western diet (B) on FoxO-mediated gene regulation and associated pathologies. GHR*, growth hormone receptor loss of function mutation in Laron syndrome; GIP, gluco |
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