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English: Lactoferrin (LTF) affinity to “danger signal” receptors. LTF modifies the type of intracellular signaling and subsequent NF-κB activation via identified danger signal receptors [toll-like receptor (TLR)2, TLR4, and CD14]. This results in a modified subset of proteins to control and contain the inflammatory response. LTF may also act via other additional signaling receptors, such as RAGE or TREM-1, which also utilize NF-κB activation pathways.
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Source https://www.researchgate.net/figure/Lactoferrin-LTF-affinity-to-danger-signal-receptors-LTF-modifies-the-type-of_fig2_320872705
Author Marian L Kruzel, Michał Zimecki, Jeffrey Actor

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6 November 2017

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